https://doi.org/10.4081/uij.2022.287

Treatment of mild to moderate stress urinary incontinence with a novel polycaprolactonebased bioresorbable urethral bulking agent

Vol. 34 No. 1 (2022)
Published: 23 May 2022
Bulking agent, bioresorbable, minimally invasive, polycaprolactone, PCL, stress urinary incontinence
Abstract Views: 1882
PDF: 449
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Authors

Evert L. Koldewijn
https://orcid.org/0000-0002-7537-7684
Department of Urology, Catharina Hospital, Eindhoven, Netherlands.
Dennis J.A.J. Oerlemans
https://orcid.org/0000-0002-6442-5652
Department of Urology, Laurentius Hospital, Roermond, Netherlands.
Alexander Beulens
research@beulensmedical.nl
https://orcid.org/0000-0002-7105-1011
Department of Urology, Catharina Hospital, Eindhoven, Netherlands.
Michel J.A.M. de Wildt
https://orcid.org/0000-0003-4119-3630
Department of Urology, Catharina Hospital, Eindhoven, Netherlands.
Vera Vandoninck
Department of Urology, Laurentius Hospital, Roermond, Netherlands.
Stefan De Wachter
https://orcid.org/0000-0002-6183-9251
Department of Urology, Antwerp University Hospital, Edegem, Belgium; Department of Urology, Antwerp Surgical Training, Anatomy and Research Centre (ASTARC), Faculty of Medicine and Health Sciences, Wilrijk, Netherlands.

A fully bioresorbable polycaprolactonebased bioresorbable bulking agent was evaluated for safety and efficacy in female patients with mild to moderate stress urinary incontinence who attempted and failed prior pelvic floor muscle training. Fifty female subjects were treated by transurethral sub-mucosal injection. Safety was evaluated over a 24-monts follow-up period. At the 12-months visit, a cystoscopy was performed for visual inspection of the injected area. Efficacy was assessed with the same intervals with the Stamey Grading System (SGS) among others. Only 6/50 subjects reported transient mild adverse events. The results show for the SGS grade more than 55% of the participants had an improvement in SGS grade, 40% of whom were cured within the first 12 months after treatment. During the second year of follow- up the effect seems to falter with an improvement of 50% of the subjects of whom 25% were cured. The results of the study suggest that treatment of mild-tomoderate stress urinary incontinence with a bioresorbable PCL-based bulking agent is a safe and effective alternative to permanent bulking agents and intermediate treatment option before the use of the permanent midurethral sling.

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Treatment of mild to moderate stress urinary incontinence with a novel polycaprolactonebased bioresorbable urethral bulking agent. (2022). Urogynaecologia, 34(1). https://doi.org/10.4081/uij.2022.287

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