https://doi.org/10.4081/uij.2023.306

Impact of vaginal submucosal platelet-rich plasma combined with non-cross-linked hyaluronic acid injections on dyspareunia and sexual satisfaction in a Hodgkin lymphoma cancer survivor: a case report

Vol. 35 No. 1 (2023)
Submitted: 25 March 2023
Accepted: 16 May 2023
Published: 30 May 2023
platelet-rich plasma, vulvovaginal atrophy, cancer, hyaluronic acid
Abstract Views: 733
PDF: 138
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Authors

Salma Samir Omar
salma.samir@alexmed.edu.eg
https://orcid.org/0000-0001-9546-4366
Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Khaled F. Elmulla
Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Noran Abo Khadr
Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Ahmed Ashour Badawy
Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Eman Nabih Ramadan
https://orcid.org/0009-0006-6931-4106
Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Ahmed Hassouna
https://orcid.org/0009-0008-6572-927X
Consultant of Gynaecology and Obstetrics, Elshatby University Hospital, Alexandria University, Alexandria, Egypt.
Lamia Heikal
Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.
Waleed Arafat
https://orcid.org/0000-0002-6617-5992

Vaginal atrophy is a commonly encountered problem among young cancer survivors. Patients suffer from vaginal dryness, irritation, and dyspareunia secondary to oestrogen deficiency. Oestrogenbased hormone replacement therapy is effective, but unfortunately health concerns or contraindications in cancer survivors frequently limit its use. A 35-year-old female patient with dyspareunia that markedly affected her sexual relationship was referred to the gynaecology clinic. Treatment using topical oestrogen cream and sexual counselling were not successful. We treated her using two submucosal injections of PRP-non-cross-linked hyaluronic acid injections into the vestibule and lower third of the anterior vaginal wall mucosa, spaced a month apart. The patient reported marked reduction of dyspareunia and demonstrated an improvement of FSFI total score 1 month after the second injection. Both the patient and her husband showed an improvement of the index of sexual satisfaction score one month after the second injection compared to their pretreatment scores. Examination of the vaginal mucosa showed improvement of thickness and integrity of the mucosa and increased lubrication. PRP-non-cross-linked hyaluronic acid submucosal injections can be effective for cancer therapy-related vaginal atrophy, coitus-related pain, and sexual satisfaction.

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Khaled F. Elmulla, Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University, Alexandria

 

 

Noran Abo Khadr, Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University, Alexandria

 

 

Ahmed Ashour Badawy, Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Alexandria University, Alexandria

 

 

Eman Nabih Ramadan, Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University, Alexandria

 

 

Ahmed Hassouna, Consultant of Gynaecology and Obstetrics, Elshatby University Hospital, Alexandria University, Alexandria

 

 

Lamia Heikal, Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria

 

 

Waleed Arafat

 

 

How to Cite

Omar, S. S., Elmulla, K. F., Abo Khadr, N., Ashour Badawy, A., Nabih Ramadan, E., Hassouna, A., … Arafat, W. (2023). Impact of vaginal submucosal platelet-rich plasma combined with non-cross-linked hyaluronic acid injections on dyspareunia and sexual satisfaction in a Hodgkin lymphoma cancer survivor: a case report. Urogynaecologia, 35(1). https://doi.org/10.4081/uij.2023.306
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