https://doi.org/10.4081/uij.2017.201

Time of symptom onset and histologic findings in bladder pain syndrome/interstitial cystitis: new findings on useful correlations

Vol. 30 No. 1 (2017)
Submitted: 20 June 2017
Accepted: 2 October 2017
Published: 5 October 2017
Interstitial cystitis, bladder pain syndrome, bladder biopsy, chronic pelvic pain.
Abstract Views: 1066
PDF: 300
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Authors

Daniele Porru
danieleporru@tin.it
Department of Urology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Valentina Bobbi
Department of Urology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Carmelo Di Franco
Department of Urology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Alessandra Viglio
Department of Molecular Medicine, Pathology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Mattia Novario
Department of Molecular Medicine, Pathology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Carmine Tinelli
Clinical Epidemiology and Biometric Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Barbara Gardella
Obstetric and Gynecological Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Rossella Nappi
Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, Research Center of Reproductive Medicine, Unit of Gynecological Endocrinology and Menopause, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Arsenio Spinillo
Obstetric and Gynecological Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Marco Paulli
Department of Molecular Medicine, Pathology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Bruno Rovereto
Department of Urology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
The aim was to find out whether a correlation exists between denudation of urothelium and time of symptom onset in patients with bladder pain syndrome/interstitial cystitis (BPS/IC), and to search a correlation between impact of symptoms evaluated with ICSI-ICPI and the presence of comorbid conditions associated with BPS/IC. Ninety-seven consecutive patients underwent cystoscopy under general anesthesia to classify those cases suspected of being affected from BPS/IC. Three cold bladder biopsies were taken including detrusor muscle. Statistical analysis showed significant correlation between IC/BPS duration and the presence of Hunner’s lesions (P<0.023). Hunner’s lesion with cystoscopy and histological evidence of urothelial denudation with bladder biopsy appear to be items related to IC/BPS duration. Thus an early diagnosis allows to start an appropriate therapeutic approach and prevent a more severe evolution of this multifaceted painful syndrome. Our study shows a correlation between time of symptom onset and evidence of urothelial denudation and with detrusor mast cell count in the whole group of patients. IC/BPS duration seem to correlate with the presence of associated diseases.

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Daniele Porru, Department of Urology, Fondazione IRCCS Policlinico San Matteo, Pavia

S.C. Urologia

Dirigente medico 1° livello

How to Cite

Porru, D., Bobbi, V., Di Franco, C., Viglio, A., Novario, M., Tinelli, C., … Rovereto, B. (2017). Time of symptom onset and histologic findings in bladder pain syndrome/interstitial cystitis: new findings on useful correlations. Urogynaecologia, 30(1). https://doi.org/10.4081/uij.2017.201

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