Time of symptom onset and histologic findings in bladder pain syndrome/interstitial cystitis: new findings on useful correlations

Submitted: 20 June 2017
Accepted: 2 October 2017
Published: 5 October 2017
Abstract Views: 1068
PDF: 300
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Authors

The aim was to find out whether a correlation exists between denudation of urothelium and time of symptom onset in patients with bladder pain syndrome/interstitial cystitis (BPS/IC), and to search a correlation between impact of symptoms evaluated with ICSI-ICPI and the presence of comorbid conditions associated with BPS/IC. Ninety-seven consecutive patients underwent cystoscopy under general anesthesia to classify those cases suspected of being affected from BPS/IC. Three cold bladder biopsies were taken including detrusor muscle. Statistical analysis showed significant correlation between IC/BPS duration and the presence of Hunner’s lesions (P<0.023). Hunner’s lesion with cystoscopy and histological evidence of urothelial denudation with bladder biopsy appear to be items related to IC/BPS duration. Thus an early diagnosis allows to start an appropriate therapeutic approach and prevent a more severe evolution of this multifaceted painful syndrome. Our study shows a correlation between time of symptom onset and evidence of urothelial denudation and with detrusor mast cell count in the whole group of patients. IC/BPS duration seem to correlate with the presence of associated diseases.

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Daniele Porru, Department of Urology, Fondazione IRCCS Policlinico San Matteo, Pavia

S.C. Urologia

Dirigente medico 1° livello

How to Cite

Porru, D., Bobbi, V., Di Franco, C., Viglio, A., Novario, M., Tinelli, C., … Rovereto, B. (2017). Time of symptom onset and histologic findings in bladder pain syndrome/interstitial cystitis: new findings on useful correlations. Urogynaecologia, 30(1). https://doi.org/10.4081/uij.2017.201

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