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Amiodarone-induced pulmonary toxicity

Junichi Ochi, Minoru Ohkouchi, Yoshikazu Tsukada, Shinichiro Tominaga, Satoshi Takayama, Yuko Taniguchi, Yumi Miyamoto, Naohiko Inase
  • Junichi Ochi
    Department of Pulmonary Medicine, Yokosuka Kyosai Hospital, Kanagawa, Japan, Japan
  • Minoru Ohkouchi
    Department of Pulmonary Medicine, Yokosuka Kyosai Hospital, Kanagawa, Japan, Japan | ninase.pulm@tmd.ac.jp
  • Yoshikazu Tsukada
    Department of Pulmonary Medicine, Yokosuka Kyosai Hospital, Kanagawa, Japan, Japan
  • Shinichiro Tominaga
    Department of Pulmonary Medicine, Yokosuka Kyosai Hospital, Kanagawa, Japan, Japan
  • Satoshi Takayama
    Department of Pulmonary Medicine, Yokosuka Kyosai Hospital, Kanagawa, Japan, Japan
  • Yuko Taniguchi
    Department of Pulmonary Medicine, Yokosuka Kyosai Hospital, Kanagawa, Japan, Japan
  • Yumi Miyamoto
    Department of Pulmonary Medicine, Yokosuka Kyosai Hospital, Kanagawa, Japan, Japan
  • Naohiko Inase
    Department of Pulmonary Medicine, Yokosuka Kyosai Hospital, Kanagawa and Integrated Pulmonology, Tokyo Medical and Dental University, Japan, Japan

Abstract

Amiodarone-induced pulmonary toxicity is a critical and potentially fatal side effect of amiodarone. Our study was designed to reveal its clinical features, including KL-6, as an interstitial marker. The medical records of eight patients (five men and three women) with amiodarone-induced pulmonary toxicity, who had been referred to our hospital, were examined. The mean age at the initiation of amiodarone was 48 years (range, 54-87 years) and mean duration of medication prior to the development of pulmonary toxicity was 18 months (range, 7-33 months). Serum KL-6 was elevated in six of the eight patients with a range of 525-2915 U/mL. Chest computed tomography (CT) findings showed non-segmental consolidation and/or ground glass opacity. Foamy macrophages were found in bronchoalveolar lavage (BAL) fluids of all examined patients and in transbronchial lung biopsy (TBLB) specimens in half of the examined patients. We concluded that serum KL-6, chest CT findings, and foamy macrophages in BAL fluids and TBLB specimens will be helpful for the diagnosis of amiodarone-induced pulmonary toxicity.

Keywords

amiodarone, pulmonary toxicity, KL-6, foamy macrophage.

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Submitted: 2011-03-02 05:05:18
Published: 2011-06-22 15:45:10
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Copyright (c) 2011 Junichi Ochi, Minoru Ohkouchi, Yoshikazu Tsukada, Shinichiro Tominaga, Satoshi Takayama, Yuko Taniguchi, Yumi Miyamoto, Naohiko Inase

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